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Using two separate drugs to shed weight can be very effective you can find combinations before the FDA now awaiting approval. When dealing with weight loss and the those who go through it you should err on the side of caution and permit the FDA do its job and demand some study be done so the public is aware of the side effects and hazards of the medications before we take them. Keep in mind that drug companies will be in business to generate money and that they would say everything to keep people on their own medications. Researchers discovered that participants investing in this drug for any year, lost weight within 4 weeks and have kept the body weight off through the 56 weeks from the study. Contrave is a combination in the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs that are made up of several active ingredient, which might make them more efficient and safer. Combo-pilling could be the newest fad or in addition to this the newest to come under scrutiny and thus it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills has become popular is the fact that since right now there aren't long term prescription diet pills that have been authorized by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be licensed by the FDA. Seizures can be a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug could also raise blood pressure levels and heartbeat, and must not be used in people with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure and heartrate and must stop used in patients with uncontrolled high blood pressure level, and also by a person with heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients with a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients to the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stopping smoking. Other people who must avoid using Contrave are patients struggling with bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave mustn't be prescribed for women who are pregnant or looking to become pregnant.