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Contrave is really a combination in the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which can be made up of many active ingredient, which may make them more potent and safer. Combo-pilling could be the newest fad or even better the newest in the future under scrutiny and thus it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills is now popular may be the fact that as of right now there are no long term prescription slimming capsules that have been authorized by the FDA apart from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations are already rejected or have yet to be authorized by the FDA. Seizures can be a side effect with Contrave and shouldn't be taken in people who have seizure disorders. The drug can also raise blood pressure level and heartrate, and really should not be used in individuals with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure and heartrate and must not used in patients with uncontrolled high blood pressure level, as well as by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients with a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert medical professionals and patients towards the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation. The most common side effects reported with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.