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Contrave is a combination in the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs which can be made up of multiple active ingredient, which might make them far better and safer. Combo-pilling could be the newest fad or even better the newest into the future under scrutiny and thus it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills has become popular is the fact that since right now there aren't any long term prescription slimming capsules that have been licensed by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be licensed by the FDA. Seizures certainly are a side effect with Contrave and really should not be taken in individuals with seizure disorders. 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